Did you know that in the pick-6 lottery game, the lotto combination 123456 is guaranteed to lose?

Mathematicians who are not

free lotto familiar with the lotto game like to claim that every set of six lotto numbers has the same chance of winning as any other. But that simply is not the case.

Having carefully analyzed the drawing results of more than 200 different lottery games worldwide - with histories going back as far as 1955 - I have verified the following incredibly simple rule based on logical calculation of the probabilities:

That which is MOST POSSIBLE happens MOST OFTEN.

That which is LEAST POSSIBLE happens LEAST OFTEN.

So, the basis of my lottery strategies is to play the probabilities -- to play that which is most likely to happen. If you play a pattern that occurs only five percent of the time, you can expect that pattern to lose 95 percent of the time. If something rarely or never happens in lottery drawings, or if something has never happened before in the history of any lotto game, shouldn't common sense tell even a math professor not to expect that thing to happen for the very first time just because he bet on it? Why place roadblocks on the path to winning?

Here are 10 reasons why you should never spend a buck on the toxic six-number lotto combination 123456. Read on and see why these eternally doomed, wretched six lotto numbers, 123456, should never be marked as a set on your bet slip.

1) CONSECUTIVE NUMBERS. My common sense formula tells you never to play six consecutive lotto numbers on one game panel. Six consecutive numbers have never been drawn in any state or international lotto game. Even five consecutive numbers is a very rare occurrence that, in most pick-6 lotto games, has never happened once.

2) ONE NUMBER GROUP. Nor should you play all six numbers from one number group, such as all single digits, or all teens, or all twenties, etc. All six winning numbers being drawn from one number group is highly unlikely - since it has never happened before in any lotto game, in America or elsewhere.

3) PATTERN BET. Avoid pattern betting. Patterns of numbers marked in a row to make a straight line - either across the bet slip or vertically or diagonally - are played by thousands in every drawing. If such numbers won, the pay-outs would be very low.

4) NEIGHBORING NUMBERS. Neighboring numbers are numbers on either side of a lotto number. For example, the neighboring numbers of 28 are 27 and 29. Less than seven percent of pick-6 lotto drawings have even four neighboring numbers.

5) ALL LOW, NOT HALF LOW. Winning numbers are usually spread across the entire number field. If we take a number field and cut it in half, we have the low half or the high half. In a 49-number game, numbers 1 to 24 are in the low half, and numbers 25 to 49 are in the high half. All high or all low numbers are rarely drawn, occurring only two percent of the time.

6) CALENDAR NUMBERS. The natural tendency of novice lotto players is to bet the lower numbers, especially the calendar numbers of 1 to 31, because of the heavy play given to birth dates, anniversary dates and children's ages. This means that the most heavily played numbers are 1 through 31. Most pick-6 lotto games have upwards of 40 or 50 numbers. If the calendar numbers do win, the first prize jackpot is greatly diminished if divided among possibly dozens of other winners. (Notice the consistently low prize payouts when four or more numbers are on the lower end of the range. The prize payouts are always higher when the higher numbers hit because fewer winners are sharing the prize pool. Notice also that in drawings where there is no jackpot winner, the winning numbers are usually higher than normal.)

7) TAIL END OF BELL CURVE. Lottery numbers are randomly drawn. If you want to play lotto to win, it is important to select your lotto numbers and place them on your bet slips in patterns that are most similar to the way the numbers are actually drawn. When you add up the six winning numbers in your state's lotto game, you get a sum. Add up the six winning numbers for several of the drawings, and you will find that most of the winning combinations tend to fall within the same range of sums.

A typical lotto 6/49 drawing could add up to 150: 3 + 17 + 23 + 24 + 36 + 47 = 150

In a 6/49 lotto game, the sums range from as low as 21 to as high as 279.

In a 49-number field, there is only one six-number combination that adds up to 21:

1 + 2 + 3 + 4 + 5 + 6 = 21

And, in the 6/49 lotto game, only one six-number combination adds up to 279:

44 + 45 + 46 + 47 + 48 + 49 = 279

Those two combinations have the smallest and largest possible sums. And they occur only once -- at the tail ends of a bell curve, making it virtually impossible for either of those groups of numbers to be drawn as a winning combination.

In the 49-number, pick-6 lotto game, the most frequently occurring sum is 150, which is the midpoint sum.

The sums of lotto combinations can be compared to the sums of combinations on a pair of dice. On either end of a bell curve, there is only one way to make a 12 (boxcars, 6 and 6), and there is only one way to make a 2 (snake eyes, 1 and 1). But there are six ways to make a 7 -- the top center point of a bell curve for a pair of dice. These combinations are 6 and 1, 1 and 6, 5 and 2, 2 and 5, 4 and 3, 3 and 4. So, of course, it is much easier to throw a 7 in dice than any other number because there are more ways of getting the sum of 7.

8) NOT A BALANCED GAME. A balanced game is a set of six numbers that falls within the Most Probable Range of Sums.

9) FALLS SHORT OF THE 70 PERCENT MOST PROBABLE RANGE OF SUMS. In a 6/49 lotto game, 27.4 percent of the sums fall within the sum range of 115 to 185 but account for 71.32 percent of the jackpot winning combinations! This means that if you play a six-number combination with a sum that falls either above or below the 115 to 185 range, you can expect that the numbers with the sum you selected will fail to show up, giving you no chance to win, 71 percent of the time.

If you want to give your odds more leverage - that is, play with the probabilities more in your favor - use my "70-Percent Rule," and see to it that the sums of your lotto bets fall within the most probable range for the lotto game you play. The range of sums varies with the number field of the lotto game. For example, my 70 percent Most Probable Range of Sums® for the popular Fantasy 5 5/39 game is 75 to 125.

10) 20,000 TICKETS SOLD EACH DRAWING. If reasons 1 through 9 have not convinced you to avoid the guaranteed losing combination, which is 01-02-03-04-05-06, then reason number 10 should. A ten-million-dollar cash jackpot would net each of 20,000 first-prize winners just $500.

Gail Howard is the author of "Lottery Master Guide" and four other quality lottery books as well as lotto software with scientific strategies and easy-to-use combinatorial systems to help the lottery player bet smarter. Gail Howard is America's original pioneer of scientific lottery strategy. She created her lottery systems in 1982 and has been publishing them for 26 years. Her web site has been online for more than twelve years. Gail Howard's web site has six pages of free lottery tips and strategies for playing lotto smarter for each of more than 200 pick 6 lotto, pick 7 and cash 5 games in the USA and around the world; also powerball, mega millions and other multi-state lottery games. No sign-in is required. Also, you can use several free interactive 30-second lotto wheels that have already won first prize jackpots. Read newspaper and magazine articles about Gail Howard's first prize lottery jackpot winners, see their photos and read their letters and stories.